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Related Experiment Video

Updated: Jun 11, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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Reconstruction of Chitosan Network Orders Using the Meniscus Splitting Method for Designing pH-Responsive Materials.

Thi Kim Loc Nguyen¹, Yoshiya Tonomura¹, Nobuaki Ito²

¹Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 31, 2024

Summary

Researchers developed a novel chitosan material with ordered microstructures using meniscus splitting. This anisotropic hydrogel exhibits directional pH-responsive swelling, offering potential as a sustainable alternative to plastics.

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Area of Science:

Materials Science
Polymer Chemistry
Biomaterials

Background:

Chitosan, derived from chitin, is a biocompatible polymer with potential as a sustainable alternative to synthetic plastics.
While chitosan's microstructures are understood, creating millimeter-scale anisotropic materials remains a challenge.

Purpose of the Study:

To develop a method for creating millimeter-scale chitosan materials with ordered microstructures.
To investigate the anisotropic pH-responsive properties of the fabricated chitosan membranes.

Main Methods:

Utilized the meniscus splitting method to reconstruct a chitosan network from an aqueous solution.
Formed chitosan membranes via ordered deposition driven by capillary forces during controlled evaporation between two air-liquid interfaces.

Main Results:

Successfully created millimeter-scale chitosan membranes with three-dimensionally ordered microstructures and microlayers.
Demonstrated directional swelling in aqueous environments and reversible/irreversible swelling-deswelling behavior controlled by pH.

Conclusions:

The meniscus splitting method enables the fabrication of anisotropic chitosan hydrogels with tunable pH responsiveness.
These chitosan materials show promise for applications under physiological conditions as next-generation functional materials.