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Updated: Jun 25, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Molecular Alterations in Pediatric Solid Tumors

Jonathan C Slack1, Alanna J Church2

  • 1Pathology & Laboratory Medicine Institute (Robert J. Tomsich), Cleveland Clinic, Cleveland, OH, USA.

Clinics in Laboratory Medicine
|May 31, 2024
PubMed

Insights

This review summarizes key molecular changes in pediatric solid tumors, impacting diagnosis and treatment. It highlights sequencing techniques and their integration into pediatric cancer pathology.

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Pediatric tumors encompass hematologic malignancies, central nervous system tumors, and extracranial solid tumors.
  • Molecular alterations significantly influence diagnosis, prognosis, treatment, and hereditary cancer risk in pediatric solid tumors.

Purpose of the Study:

  • To summarize clinically relevant molecular alterations in extracranial pediatric solid tumors.
  • To discuss molecular techniques and their integration into diagnostic pathology for pediatric solid tumors.

Main Methods:

  • Review of literature on molecular alterations in extracranial pediatric solid tumors.
  • Discussion of conventional and next-generation sequencing techniques.
  • Examination of tumor predisposition syndromes.

Main Results:

  • Clinically relevant molecular alterations in pediatric solid tumors are identified.
  • Conventional and next-generation sequencing methods are detailed.
  • The role of molecular data in diagnostic pathology for pediatric solid tumors is explored.

Conclusions:

  • Molecular profiling is crucial for understanding and managing pediatric solid tumors.
  • Advancements in sequencing technologies enhance diagnostic capabilities.
  • Integrating molecular data improves the diagnostic pathology practice for pediatric cancers.
Keywords:
MolecularPediatric pathologySoft tissue and bone tumorsSolid tumors

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