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Tumor Progression02:07

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Molecular Alterations in Pediatric Solid Tumors.

Jonathan C Slack1, Alanna J Church2

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Clinics in Laboratory Medicine
|May 31, 2024
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Summary
This summary is machine-generated.

This review summarizes key molecular changes in pediatric solid tumors, impacting diagnosis and treatment. It highlights sequencing techniques and their integration into pediatric cancer pathology.

Keywords:
MolecularPediatric pathologySoft tissue and bone tumorsSolid tumors

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Pediatric tumors encompass hematologic malignancies, central nervous system tumors, and extracranial solid tumors.
  • Molecular alterations significantly influence diagnosis, prognosis, treatment, and hereditary cancer risk in pediatric solid tumors.

Purpose of the Study:

  • To summarize clinically relevant molecular alterations in extracranial pediatric solid tumors.
  • To discuss molecular techniques and their integration into diagnostic pathology for pediatric solid tumors.

Main Methods:

  • Review of literature on molecular alterations in extracranial pediatric solid tumors.
  • Discussion of conventional and next-generation sequencing techniques.
  • Examination of tumor predisposition syndromes.

Main Results:

  • Clinically relevant molecular alterations in pediatric solid tumors are identified.
  • Conventional and next-generation sequencing methods are detailed.
  • The role of molecular data in diagnostic pathology for pediatric solid tumors is explored.

Conclusions:

  • Molecular profiling is crucial for understanding and managing pediatric solid tumors.
  • Advancements in sequencing technologies enhance diagnostic capabilities.
  • Integrating molecular data improves the diagnostic pathology practice for pediatric cancers.