Amplification sensing manipulated by a sumanene-based supramolecular polymer as a dynamic allosteric effector

Area of Science:

• Supramolecular Chemistry
• Chemical Sensing
• Materials Science

Background:

• Signal amplification is crucial for sensitive detection but challenging to control.
• Existing chemosensor systems often lack flexibility in signal manipulation.
• Dynamic control over signal amplification remains an unmet need in multidisciplinary sciences.

Purpose of the Study:

• To develop a novel signal-amplification system controllable by a dynamic allosteric effector.
• To utilize supramolecular polymerization for flexible manipulation of signal amplification degree.
• To provide an alternative to conventional chemosensors and signal amplification strategies.

Main Methods:

• Employed a curved-π buckybowl sumanene as a dynamic allosteric effector.
• Utilized a sumanene-based chemosensor (SC) as the molecular binder.
• Constructed a hetero-supramolecular polymer, (SC·(sumanene)n), to control polymerization degree via monomer concentration.

Main Results:

• Demonstrated flexible manipulation of the signal amplification degree through dynamic allosteric control.
• Achieved up to a 62.5-fold signal amplification for a steroid analyte.
• Successfully controlled the degree of polymerization by adjusting sumanene monomer concentration.

Conclusions:

• The developed system offers a novel approach to signal amplification in chemosensors.
• Dynamic allosteric effectors provide a flexible method for controlling supramolecular polymerization.
• This strategy presents a viable alternative to conventional signal amplification techniques.