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Updated: Jun 24, 2025

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Phage Display as a Medium for Target Therapy Based Drug Discovery, Review and Update.

Samaneh Jahandar-Lashaki1,2, Safar Farajnia3,4, Aref Faraji-Barhagh1

  • 1Medical Biotechnology Department, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

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|June 1, 2024
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Summary

Phage display technology enables the discovery of high-affinity antibodies and peptides for targeted therapies. This review highlights its crucial role in treating cancers, infectious diseases, and neurological disorders.

Keywords:
AntibodyCAR T-cellDrug deliveryGene therapyPeptidePhage displayTargeted therapy

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Immunology

Background:

  • Phage display is a powerful technique for identifying high-affinity antibodies and peptides.
  • It has significant applications in targeted therapy due to its ability to discover specific binding candidates.
  • Several phage display-derived products are approved by the FDA for disease treatment.

Purpose of the Study:

  • To provide a comprehensive review of phage display applications in medicine.
  • To explore the role of phage display-derived peptides and antibodies in treating various diseases.
  • To discuss emerging applications in drug delivery, gene therapy, and CAR T-cell therapy.

Main Methods:

  • Biopanning process to identify specific binding phage clones.
  • Screening of large phage libraries containing billions of displayed phages.
  • Review of existing literature on phage display applications and therapeutic outcomes.

Main Results:

  • Phage display facilitates the identification of high-affinity peptides and antibodies.
  • Demonstrated success in developing therapeutic candidates for cancers, infectious diseases, and neurological disorders.
  • Expanding applications in targeted drug delivery, gene therapy, and CAR T-cell therapy.

Conclusions:

  • Phage display is a versatile and effective platform for therapeutic and diagnostic development.
  • Its applications continue to expand, offering new avenues for treating complex diseases.
  • The technology holds significant promise for future advancements in personalized medicine and novel therapeutics.