Related Experiment Video

Updated: Jun 24, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
07:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

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Aberrant angiogenic signaling pathways: Accomplices in ovarian cancer progression and treatment

Wenchao Zhou1, Tian Zeng1, Junling Chen2

  • 1Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Cellular Signalling
|June 1, 2024
PubMed

Insights

This review explores antiangiogenic therapies targeting the tumor microenvironment (TME) in ovarian cancer. Understanding signaling pathway interactions is key to developing new treatments for this common women's cancer.

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • Ovarian cancer presents limited treatment options, necessitating novel therapeutic strategies.
  • The tumor microenvironment (TME) plays a critical role in ovarian cancer progression and metastasis.
  • Angiogenesis, the formation of new blood vessels, is a key process within the TME that supports tumor growth.

Purpose of the Study:

  • To review the latest advancements in targeting angiogenic signaling pathways within the ovarian cancer TME.
  • To explore the potential of antiangiogenic therapies for ovarian cancer treatment.
  • To highlight the importance of understanding pathway crosstalk for effective TME-based therapies.

Main Methods:

  • Comprehensive literature review of recent studies on ovarian cancer angiogenesis.
  • Analysis of signaling pathways involved in tumor neovascularization.
  • Examination of therapeutic strategies targeting these pathways.

Main Results:

  • Abnormal and hyperactive neovascularization signaling pathways are prevalent in ovarian cancer TME.
  • Inhibition of these pathways shows promise for therapeutic effects, including overcoming drug resistance.
  • Complex crosstalk and correlations exist between TME signaling pathways.

Conclusions:

  • Targeting angiogenic signaling pathways in the ovarian cancer TME offers a promising therapeutic avenue.
  • Further research into pathway interactions is crucial for optimizing antiangiogenic TME therapies.
  • Understanding these mechanisms may lead to improved treatment outcomes and reversal of drug resistance in ovarian cancer.
Keywords:
AngiogenesisInhibitorOvarian cancerPathways

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