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Updated: Jun 24, 2025
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Late Kidney Injury After Admission to Intensive Care Unit for Acute Heart Failure
Masaki Morooka1, Akihiro Shirakabe1, Hirotake Okazaki1
1Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School.
International Heart Journal
|June 2, 2024
Summary
Late kidney injury (LKI) in acute heart failure (AHF) patients is linked to prior hospital acute kidney injury (AKI). AKI during hospitalization predicts LKI, which independently predicts 3-year mortality in AHF patients.
Area of Science:
- Nephrology
- Cardiology
- Intensive Care Medicine
Background:
- Late kidney injury (LKI) in acute heart failure (AHF) patients requiring intensive care is not well understood.
- Defining and predicting LKI is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the association between acute kidney injury (AKI) during hospitalization and the development of LKI in AHF patients.
- To determine if LKI is an independent predictor of long-term mortality in this population.
Main Methods:
- Analysis of 821 AHF patients admitted to intensive care.
- LKI defined by creatinine ratio 1 year post-admission; AKI assessed during hospitalization.
- Multivariate logistic and Cox regression analyses used to identify predictors of LKI and mortality.
Main Results:
- Hospitalization AKI was independently associated with LKI (ORs ranging from 1.710 to 9.259).
- LKI was an independent predictor of 3-year all-cause death (HR: 1.545).
- Outcomes were worse in patients with LKI, particularly those who also had AKI during hospitalization.
Conclusions:
- The incidence of LKI is influenced by prior AKI during hospitalization.
- LKI is a significant predictor of poor outcomes, including 3-year mortality, in AHF patients.
- In the absence of LKI, AKI during hospitalization for AHF did not appear to be associated with poor outcomes.
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