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Decreased histone expression in chronic rhinosinusitis with nasal polyps
Yanming Zhao1, Nan Zhang2, Claudina Perez Novo2
1Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Asia Pacific Allergy
|June 3, 2024
Summary
Histone H2BK may play a role in chronic rhinosinusitis (CRS). Reduced expression of this histone in nasal polyps might disrupt cell balance, potentially contributing to CRS with nasal polyps.
Area of Science:
- Biochemistry
- Immunology
- Pathophysiology
Background:
- Histones are linked to various human diseases.
- The role of extranuclear histones in chronic rhinosinusitis (CRS) pathophysiology remains under-investigated.
- This study aimed to explore histone involvement in CRS.
Purpose of the Study:
- To investigate the expression of histones in patients with CRS.
- To elucidate the potential mechanism of histones in the pathogenesis of CRS with nasal polyps (CRSwNP).
Main Methods:
- Gene expression profiling of nasal polyp tissues using microarray analysis.
- Validation of expression differences via reverse transcriptase polymerase chain reaction and immunohistochemical staining.
- Cell culture and flow cytometry to assess histone function in polyp pathogenesis.
Main Results:
- Significant differences in gene expression were identified between CRS patients and controls (P < 0.01).
- Histone H2BK was found to promote apoptosis in nasal polyps via flow cytometry analysis.
Conclusions:
- Reduced expression of Histone H2BK may be implicated in the dysregulation of cell proliferation and apoptosis observed in CRSwNP.
- Histones, particularly H2BK, represent a potential factor in the pathophysiology of CRS.
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