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Circulating microaggregates as biomarkers for the Post-COVID syndrome
M Hermann1, C Lisch2, R Gerth3
1Department of Anesthesia and Intensive Care, Medical University Innsbruck, Austria.
Idcases
|June 3, 2024
Summary
Post-COVID syndrome may involve blood microaggregates and viral reactivation. Treating these with anticoagulants and antivirals led to patient recovery and symptom remission, suggesting a new diagnostic indicator.
Area of Science:
- Immunology
- Hematology
- Virology
Background:
- CoVID-19 can lead to Post-COVID syndrome with significant morbidity.
- Hypothesized mechanisms include procoagulation and reactivation of dormant viruses like Epstein-Barr virus (EBV).
Observation:
- A patient presented with fatigue, post-exertional malaise, pain, and neurological symptoms after a second CoVID infection.
- Live confocal microscopy revealed microaggregates of platelets, leukocytes, and plasma proteins in peripheral blood.
- Specific cellular immune reactivity to EBV was detected.
Findings:
- Anticoagulatory and virustatic therapy resulted in the dissolution of observed microaggregates.
- The patient achieved significant and stable clinical remission of symptoms.
Implications:
- Circulating microaggregates may serve as a morphological indicator for chronic Post-COVID syndrome.
- This finding suggests potential therapeutic targets for managing long COVID symptoms.
- Further research into microaggregate formation and EBV reactivation in Post-COVID syndrome is warranted.
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