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The structure and function of FUN14 domain-containing protein 1 and its contribution to cardioprotection by mediating

Yuhu Lv1,2, Zhengze Yu3, Peiwen Zhang4

  • 1College of Physical Education, Guangdong University of Education, Guangzhou, China.

Frontiers in Pharmacology
|June 3, 2024
PubMed

Insights

FUN14 domain-containing protein 1 (FUNDC1) regulates mitophagy, a process crucial for heart health. Modulating FUNDC1-mediated mitophagy protects the heart by controlling mitochondrial quality and preventing apoptosis.

Area of Science:

  • Cardiovascular Biology
  • Cellular Mechanisms
  • Mitochondrial Dynamics

Background:

  • Cardiovascular disease (CVD) poses a significant public health challenge, necessitating effective prevention and treatment strategies.
  • The multifactorial nature of CVD complicates therapeutic approaches, highlighting the need for novel interventions.
  • Mitophagy, a selective form of autophagy, is increasingly recognized for its cardioprotective roles.

Purpose of the Study:

  • To review the structure, function, and mitophagy-regulating pathways of FUN14 domain-containing protein 1 (FUNDC1).
  • To elucidate the mechanisms by which FUNDC1-mediated mitophagy influences mitochondrial quality control and cardioprotection.
  • To explore the role of FUNDC1-mediated mitophagy in exercise preconditioning (EP) and identify future research directions.

Main Methods:

  • Literature review focusing on FUNDC1 structure, function, and mitophagy.
  • Analysis of signaling pathways regulating FUNDC1 phosphorylation and ubiquitination.
  • Exploration of FUNDC1's role in mitochondrial quality control and apoptosis.

Main Results:

  • FUNDC1 levels and post-translational modifications (phosphorylation at Ser13, Tyr18, Ser17; ubiquitination at Lys119) are critical for mitophagy regulation.
  • Modulating FUNDC1-mediated mitophagy balances mitochondrial quality control, preventing damaged mitochondria accumulation and excessive apoptosis.
  • FUNDC1-mediated mitophagy is implicated in the cardioprotective effects of exercise preconditioning.

Conclusions:

  • FUNDC1 is a key regulator of mitophagy, offering a potential target for cardiovascular disease intervention.
  • Precise control of FUNDC1-mediated mitophagy is essential for maintaining cardiac health.
  • Further research into FUNDC1 and its mitophagy pathways is warranted to develop novel cardioprotective strategies.

Keywords:
FUN14 domain-containing protein 1cardioprotectionexercise preconditioningmitochondriamitophagy

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