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Epicardial Adipose Tissue Metabolic Changes Associated with Different Intensities Interval Exercise Preconditioning
Niujin Shi1,2,3, Zhengze Yu1, Chen Lin1
1Guangxi Key Laboratory of Health Promotion and Exercise Intervention, College of Physical Education and Health, Guangxi Normal University, No. 1 Yanzhong Road, Yanshan District, Guilin, Guangxi, 541000, China.
Applied Biochemistry and Biotechnology
|May 15, 2026
Summary
Moderate-intensity exercise preconditioning effectively restores metabolic disturbances in epicardial adipose tissue following myocardial ischemia-reperfusion injury. This approach uniquely reverses key metabolic pathways, offering promising cardioprotection.
Area of Science:
- Cardiovascular Therapeutics
- Metabolomics
- Exercise Physiology
Background:
- Myocardial ischemia-reperfusion (I/R) injury presents a significant clinical challenge.
- Epicardial adipose tissue (EAT) plays a crucial role in regulating myocardial injury through paracrine signaling.
- Exercise preconditioning is a potential cardioprotective strategy, but its effects on EAT metabolism require detailed investigation.
Purpose of the Study:
- To investigate the impact of graded exercise intensities on the metabolic plasticity of EAT during I/R injury.
- To identify specific metabolic pathways in EAT that are modulated by exercise preconditioning.
- To determine the optimal exercise intensity for restoring EAT metabolic profiles after I/R injury.
Main Methods:
- Male C57BL/6 mice were subjected to 6 weeks of low-, moderate-, or high-intensity interval treadmill training.
- Mice then underwent myocardial ischemia-reperfusion (I/R) surgery.
- Untargeted metabolomics was performed on EAT samples to analyze metabolic profiles.
Main Results:
- Moderate-intensity interval exercise preconditioning uniquely restored I/R-induced metabolic disturbances in EAT.
- This normalization included significant reversal of dysregulation in bile acid biosynthesis, xenobiotic detoxification, and cholesterol metabolism.
- Low- and high-intensity protocols showed incomplete recovery of lipid homeostasis and failed to rescue oxidative stress pathways.
Conclusions:
- Exercise preconditioning induces intensity-dependent metabolic reprogramming in EAT.
- Moderate-intensity interval exercise is most effective in restoring EAT metabolic profiles following I/R injury.
- These findings highlight EAT metabolic changes associated with exercise-induced cardioprotection and suggest moderate-intensity exercise as a targeted therapeutic approach.
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