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Outcome measures for chronic rhinosinusitis with nasal polyps.
A R Sedaghat1, R G Campbell2,3,4, R G Douglas5
1Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rhinology
|June 3, 2024
Summary
New treatments for chronic rhinosinusitis with nasal polyps (CRSwNP) require robust outcome measures. This review details patient-reported outcome measures (PROMs), objective tests, psychophysical tests, and biomarkers for assessing CRSwNP.
Area of Science:
- Otolaryngology
- Clinical Trials
- Medical Diagnostics
Background:
- Novel therapeutics for chronic rhinosinusitis with nasal polyps (CRSwNP) necessitate comprehensive outcome measures.
- Existing measures include patient-reported outcome measures (PROMs) for quality of life and symptom severity.
- Objective tests, psychophysical tests, and biomarkers are also crucial for evaluating CRSwNP.
Purpose of the Study:
- To review and describe various outcome measures for CRSwNP.
- To assess the efficacy of CRSwNP treatments.
- To provide a comprehensive overview of available assessment tools.
Main Methods:
- A narrative literature review was conducted.
- Outcome measures for CRSwNP evaluation and treatment response assessment were identified and described.
- The history, validation, psychometric performance, and limitations of each measure were examined.
Main Results:
- Multiple outcome measures for CRSwNP were identified, categorized as PROMs, objective tests, psychophysical tests, or biomarkers.
- The review details the historical development and seminal studies for each measure.
- Formal validation, psychometric performance, and limitations of each outcome measure are presented.
Conclusions:
- PROMs, objective tests, psychophysical tests, and biomarkers are complementary measures for CRSwNP.
- These diverse outcome measures aid in assessing CRSwNP disease status and treatment efficacy.
- Understanding the validation, performance, and limitations of each measure is essential for accurate interpretation.
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