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Association between hyperuricemia and chronic total coronary occlusion in non-chronic kidney disease populations: a
Jianping Wang1, Xiaoli Chen2, Zhongwei He1
1Departments of Cardiology.
Insights
Hyperuricemia (HU) is linked to a higher risk of chronic total coronary occlusion (CTO) in individuals without chronic kidney disease. This association is particularly strong in younger, nonobese, and dyslipidemic patients.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Epidemiology
Background:
- Chronic total coronary occlusion (CTO) presents significant health challenges and economic burdens.
- Hyperuricemia (HU) is frequently observed in patients with atherosclerosis.
- Limited research exists on the association between HU and CTO risk, and the influence of traditional cardiovascular risk factors.
Purpose of the Study:
- To investigate the relationship between hyperuricemia and the risk of developing chronic total coronary occlusion.
- To explore the role of traditional cardiovascular risk factors in the context of HU and CTO.
Main Methods:
- A cohort of 1245 individuals without chronic kidney disease from southwest China undergoing coronary angiography was studied.
- CTO was defined as a coronary artery occlusion of over 3 months; HU was defined by specific serum uric acid levels.
- Logistic regression models and subgroup analyses were employed to assess the HU-CTO association.
Main Results:
- Adjusted analyses revealed that HU was associated with a 1.47-fold increased risk of CTO (OR, 1.47; 95% CI, 1.06-2.58; P=0.026).
- Serum uric acid levels independently predicted CTO risk (OR, 1.002; 95% CI, 1.001-1.004; P=0.047).
- Higher CTO risk was observed in individuals under 65, nonobese individuals, and those with dyslipidemia, but not significantly by sex, smoking, hypertension, or diabetes.
Conclusions:
- Hyperuricemia is associated with an elevated risk of CTO in non-CKD individuals in southwest China.
- The increased risk is particularly notable in younger (<65 years), nonobese, and dyslipidemic individuals.
- These findings highlight HU as a potential risk factor for CTO in specific patient subgroups.
Background:
Chronic total coronary occlusion (CTO) is an extremely hazardous condition that leads to various clinical phenomena and complications and results in social and economic burdens. Hyperuricemia (HU) is often associated with atherosclerosis. Few studies, however, have investigated the risk of CTO in individuals with HU and the role of traditional cardiovascular risk factors in this setting.
Methods:
A cohort of 1245 individuals without chronic kidney disease from southwest China who underwent coronary angiography between February 2018 and June 2021 were enrolled. CTO was defined as a total occlusion of any coronary artery or arteries for more than 3 months. HU was defined as a serum uric acid level of ≥420 µmol/L in men and ≥360 µmol/L in women. Univariate and multivariate logistic regression models and subgroup analyses were applied to assess the relationship between HU and CTO.
Results:
After adjustment, HU was noted to be associated with a 1.47-fold increase in the risk of CTO [odds ratio (OR), 1.47; 95% confidence interval (CI), 1.06-2.58; P = 0.026]. As a continuous variable, uric acid was an independent predictor of CTO (OR, 1.002; 95% CI, 1.001-1.004; P = 0.047). Subgroup analyses showed that the risk of CTO was higher among individuals under 65 years of age (OR, 2.77; 95% CI, 1.3-5.89), nonobese individuals (OR, 1.9; 95% CI, 1.16-3.1), and those with dyslipidemia (OR, 1.8; 95% CI, 1.04-3.11), while sex, smoking, hypertension, and diabetes did not show similar effects. Interaction analyses revealed no interaction among subgroups.
Conclusion:
Among individuals residing in southwest China, HU was associated with an increased risk of CTO in non-CKD individuals, especially those under 65 years of age and nonobese and dyslipidemic individuals.
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