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The relationship between bisphenol A and phthalates with precocious puberty in Vietnamese children

Quynh Thi Vu Huynh1,2, Ho Tran Ban3,4, Nguyen Lam Vuong5

  • 1Department of Pediatrics, 249295 University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City, Vietnam.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|June 3, 2024
PubMed

Insights

Urinary bisphenol A (BPA) and dibutylphthalate (DBP) were more prevalent in children with precocious puberty (PP). This suggests a potential link between these environmental chemicals and the early onset of puberty in children.

Area of Science:

  • Endocrinology
  • Environmental Health
  • Pediatrics

Background:

  • Precocious puberty (PP) is a condition characterized by the early onset of puberty.
  • Exposure to environmental endocrine-disrupting chemicals, such as bisphenol A (BPA) and phthalates, has been investigated for potential links to PP.

Purpose of the Study:

  • To investigate the association between urinary levels of bisphenol A (BPA), diethylhexylphthalate (DEHP), and dibutylphthalate (DBP) and the risk of precocious puberty (PP).
  • To explore the correlation between specific chemical exposures and the occurrence of PP in children.

Main Methods:

  • A case-control study was conducted in Ho Chi Minh City, Vietnam.
  • The study included 250 children: 124 diagnosed with PP (cases) and 126 without PP (controls).
  • Urinary concentrations of BPA, DEHP, and DBP were measured using validated analytical methods.

Main Results:

  • Bisphenol A (BPA) was detected in 11.3% of precocious puberty cases, but in none of the controls (p<0.001).
  • No diethylhexylphthalate metabolite (MEHP) was detected in any samples.
  • Dibutylphthalate metabolite (MBP) was found in 8.1% of PP cases and 2.4% of controls, indicating a 3.6-fold increased odds of PP (95% CI: 0.97-13.4, p=0.03).

Conclusions:

  • Children with precocious puberty showed a significantly higher prevalence of positive urinary BPA and DBP levels compared to the control group.
  • These findings suggest a potential association between BPA and DBP exposure and the development of precocious puberty.
Abstract

Keywords:
bisphenol Aphthalatesprecocious puberty

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