Related Experiment Video
Updated: May 3, 2026
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
17.3K
Chemically Programmed Hydrogels for Spatiotemporal Modulation of the Cardiac Pathological Microenvironment
Chaojie Yu1, Yuwei Qiu1, Fanglian Yao1
1School of Chemical Engineering and Technology, Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Tianjin University, Tianjin, 300350, China.
Advanced Materials (Deerfield Beach, Fla.)
|June 3, 2024
Summary
Engineered hydrogels offer targeted modulation of the heart attack microenvironment. These smart materials promote myocardial repair by addressing ischemia-hypoxia, inflammation, and scarring after myocardial infarction (MI).
Area of Science:
- Biomaterials Science
- Cardiovascular Research
- Tissue Engineering
Background:
- Myocardial infarction (MI) creates a pathological cardiac microenvironment.
- This environment is characterized by ischemia-hypoxia, oxidative stress, inflammation, and fibrosis.
- Current therapies lack targeted and responsive modulation, limiting myocardial repair.
Purpose of the Study:
- To review the pathological microenvironment post-MI.
- To explore chemically programmed hydrogels for cardiac repair.
- To discuss hydrogel strategies for modulating the infarct microenvironment.
Main Methods:
- Review of engineered hydrogels with chemical programming.
- Analysis of hydrogel strategies for minimally invasive implantation and integration.
- Discussion of responsive polymer networks, micro/nanoplatforms, and biological cues.
Main Results:
- Hydrogels can be chemically programmed for targeted delivery and responsive modulation.
- Strategies include crosslinking, interfacial binding, and topological control for myocardial integration.
- Programmed hydrogels enhance substance exchange and signal interactions.
Conclusions:
- Chemically programmed hydrogels offer precise spatiotemporal control over the cardiac microenvironment.
- These hydrogels can be designed for oxygen generation, antioxidant, anti-inflammatory, provascular, and electrointegration functions.
- This approach holds promise for advancing cardiac tissue engineering and myocardial repair.
Related Concept Videos
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
1.9K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.9K
01:25Acid-Base Balance
2.5K
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
2.5K
01:18Respiratory Regulation of Acid-Base Balance
2.3K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
2.3K
01:29Renal Regulation of Acid-Base Balance
2.5K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
2.5K
01:30Heart Failure V: Medical Management
626
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
626
01:22Heart Failure VI: Adjunct Therapies
632
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
632