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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Cognitive Development During Adulthood01:30

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Organization of the Brain01:30

Organization of the Brain

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The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Related Experiment Video

Updated: Jun 24, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Embracing complexity of (brain) aging.

M Cristina Polidori1,2

  • 1Aging Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.

FEBS Letters
|June 3, 2024
PubMed
Summary
This summary is machine-generated.

Aging causes functional loss and disease risk due to interconnected biomolecular mechanisms. Understanding these aging pillars, especially in the brain, is key to developing new therapies for cognitive decline and age-related diseases.

Keywords:
agingbiomarkerdementiafrailtyoxidative stress

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Area of Science:

  • Gerontology and Neuroscience

Background:

  • Aging is a complex process leading to functional decline and increased susceptibility to illness.
  • The brain is particularly vulnerable to aging, exhibiting hallmarks shared with neurodegenerative diseases.

Conclusions:

  • Aging is a significant risk factor for functional decline and disease, particularly affecting the central nervous system.
  • Targeting the interwoven biomolecular mechanisms of aging offers a promising avenue for developing preventive and therapeutic interventions.
  • Further research into these mechanisms is crucial for advancing strategies against age-related cognitive impairment and other diseases.