Related Experiment Video
Updated: Jun 24, 2025
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
10.9K
DO disease stages affect oxidative stress in stable COPD?
Murat Yalcinsoy1, Aysegul Beykumul2, Gazi Gulbas2
1Department of Pulmonary Medicine, Inonu University Medical Faculty, Turgut Ozal Medical Center, Malatya, Turkey.
Heliyon
|June 4, 2024
Summary
In stable Chronic Obstructive Pulmonary Disease (COPD) patients, oxidative stress levels do not differ significantly across disease stages. This finding suggests anti-inflammatory therapy may not be beneficial for stable COPD, except during exacerbations.
Area of Science:
- Pulmonary Medicine
- Biochemistry
- Clinical Research
Background:
- Oxidative stress is implicated in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis.
- Elevated oxidative stress levels are observed in stable COPD patients.
- Understanding oxidative stress in COPD may reveal new therapeutic targets.
Purpose of the Study:
- To investigate if COPD stage influences the severity of inflammation-induced oxidative stress.
- To analyze oxidative stress parameters in stable COPD patients across different GOLD stages.
Main Methods:
- Consecutive stable COPD patients were recruited from outpatient clinics (June 2019 - March 2020).
- Patients were classified into GOLD stages A, B, and E.
- Oxidative stress markers were assessed and correlated with patient characteristics and disease stage.
Main Results:
- A total of 98 patients (93.9% male, median age 65) were analyzed.
- Significant differences in FEV1, FVC, and FEV1/FVC were observed between groups (p < 0.001).
- After age adjustment, oxidative stress parameters were comparable across GOLD stages, with low-level negative correlations observed with age, thiols, and DS.
Conclusions:
- No significant differences in oxidative stress parameters were found among stable COPD patients based on GOLD classification.
- These findings suggest that routine anti-inflammatory therapy may not be indicated for stable COPD, reserving it for acute exacerbations.
More Related Videos
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:20COPD: Pathogenesis and Clinical Features
259
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
259
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:26COPD: Management Using Bronchodilators and Corticosteroids
195
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
195
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K