Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated multi-omics analysis identifies key microglial subpopulations and therapeutic targets in Parkinson's disease.

Parkinsonism & related disorders·2026
Same author

Integrating harm reduction interventions for older adults in opioid treatment programs: a qualitative study of patient and provider perspectives.

Harm reduction journal·2026
Same author

R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis.

Journal of inflammation research·2026
Same author

Establishment of In Ovo <i>Salmonella</i> Enteritidis Infection and Synbiotic Delivery Models in Chick Embryos and Their Effects on Early Gut Health.

Animals : an open access journal from MDPI·2026
Same author

Insights into Evolving Trends and Controversies in Orthopaedic Surgery from the ABOS Case Collection System: Data from Current Procedural Terminology-Specific Special Questions, 2022 to 2024.

The Journal of bone and joint surgery. American volume·2026
Same author

Research progress and interfacial adhesion mechanisms of oral delivery systems based on natural polymers.

Journal of materials chemistry. B·2026

Related Experiment Video

Updated: Jun 24, 2025

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

1.8K

Bone Health Management in Elective Orthopaedic Surgery: A Claims-Based Observational Study.

Kyle J Jeray1, Setareh A Williams2, Yamei Wang3

  • 1Orthopedic Surgery, PRISMA Health, Greenville, SC, USA.

Geriatric Orthopaedic Surgery & Rehabilitation
|June 4, 2024
PubMed
Summary
This summary is machine-generated.

Bone health management, including osteoporosis (OP) testing and treatment, is inadequate in patients undergoing orthopedic surgery. This suboptimal care is more pronounced in men compared to women.

Keywords:
bone healthkyphoplastyorthopaedic surgeryosteoporosistotal hip arthroplastytotal knee arthroplastyvertebroplasty

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.2K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.4K

Related Experiment Videos

Last Updated: Jun 24, 2025

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

1.8K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.2K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.4K

Area of Science:

  • Orthopaedic Surgery
  • Bone Health
  • Osteoporosis Management

Background:

  • Limited data exist on bone mineral density (BMD) evaluation and osteoporosis (OP) treatment in patients undergoing elective orthopaedic surgeries.
  • Bone health management is crucial for patients undergoing procedures like kyphoplasty/vertebroplasty (KP/VP), total knee arthroplasty (TKA), and total hip arthroplasty (THA).

Purpose of the Study:

  • To evaluate the management of bone health, including OP testing and treatment, in patients aged ≥50 years undergoing elective orthopaedic surgeries.
  • To identify disparities in bone health management based on surgical procedure, sex, and fracture risk.

Main Methods:

  • Retrospective cohort study utilizing administrative claims data (Symphony Health, PatientSource).
  • Included patients aged ≥50 years undergoing KP/VP, TKA, or THA.
  • Risk stratification for very high fracture risk (VHRFx) based on available clinical guideline variables.

Main Results:

  • A total of 251,919 patients were analyzed.
  • Only 11.8% of patients received OP testing and/or treatment in the 6 months prior to surgery.
  • Patients undergoing KP/VP had higher rates of testing/treatment (17.5%) compared to TKA (11.0%) or THA (11.0%).
  • Men had significantly lower rates of testing/treatment (4.6%) than women (13.5%).
  • Patients with OP and at VHRFx showed higher testing/treatment rates (30.8%) than those without OP.

Conclusions:

  • Bone health management, including OP care, is suboptimal in patients undergoing elective orthopaedic surgery.
  • Men receive poorer bone health management compared to women.
  • Improved pre- and post-operative OP management may enhance patient outcomes.