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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats
Published on: November 6, 2019
R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the
Yong Yang1, Jing Wang2, Heng Zhou3
1Department of Neurosurgery, the First Affiliated Hospital of Yangtze University, the First People's Hospital of Jingzhou, Jingzhou, Hubei, 434000, People's Republic of China.
Journal of Inflammation Research
|July 1, 2026
Summary
R788, a spleen tyrosine kinase inhibitor, shows neuroprotective effects against ischemic stroke. It alleviates oxidative stress and promotes cell survival by regulating key pathways, offering a potential therapeutic strategy for stroke treatment.
Area of Science:
- Neuroscience
- Pharmacology
- Biomedical Engineering
Background:
- Ischemic stroke is a leading cause of death and disability worldwide.
- Oxidative stress is a key factor in stroke-induced brain damage.
- Targeting regulated cell death pathways presents a promising therapeutic avenue for ischemic stroke.
Purpose of the Study:
- To investigate the therapeutic potential of R788, a spleen tyrosine kinase inhibitor, in treating ischemic stroke.
- To elucidate the underlying mechanisms of R788's neuroprotective effects.
- To evaluate R788's impact on oxidative stress and cell death pathways.
Main Methods:
- Utilized a middle cerebral artery occlusion (MCAO) mouse model and an H2O2-induced SH-SY5Y cell model for ischemic stroke (IS).
- Assessed R788's antioxidant and anti-apoptotic effects.
- Measured intracellular Fe2+ concentration, lipid peroxidation, and STAT1/Nrf2/GPX4 pathway expression.
Main Results:
- R788 treatment increased cell survival in both animal and cell models of ischemic stroke.
- R788 inhibited p-STAT1 and suppressed ferroptosis, indicating reduced oxidative stress.
- R788 demonstrated neuroprotective effects by alleviating ischemia-induced neural injury.
Conclusions:
- R788 alleviates ischemic injury and oxidative stress by regulating STAT1/Nrf2/GPX4 pathways.
- R788 exhibits significant potential as a therapeutic agent for ischemic stroke.
- This study provides novel mechanistic insights into R788's efficacy in stroke treatment.