Related Experiment Video
Updated: Jun 24, 2025
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Autoimmune hepatitis after COVID-19 infection
Alberto Pérez Ramírez1, Ignacio López Bueno1, José Manuel Sousa Martín1
1Aparato Digestivo, Hospital Universitario Virgen del Rocío, España.
A COVID-19 infection may trigger autoimmune hepatitis in adults. This case study highlights the potential link and effective treatment strategies for this condition.
Area of Science:
- Hepatology
- Immunology
- Infectious Diseases
Background:
- Acute hepatitis presentation in a 58-year-old male.
- Exclusion of biliary tract abnormalities via abdominal ultrasound.
- Recent history of COVID-19 infection (2 weeks prior).
Observation:
- Viral hepatitis was ruled out.
- Presence of autoantibodies confirmed.
- Liver biopsy revealed autoimmune hepatitis with grade 1 fibrosis.
Findings:
- Initial treatment with budesonide was ineffective.
- Switched to prednisone for acute management.
- Maintenance therapy included prednisone and azathioprine.
Implications:
- COVID-19 infection may serve as a potential trigger for autoimmune hepatitis.
- This case underscores the importance of considering autoimmune etiologies in post-viral hepatitis.
- Successful management involved corticosteroids and immunosuppressants.
More Related Videos
11:36Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Related Concept Videos
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:29Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...