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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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Autoimmune hepatitis after COVID-19 infection
Alberto Pérez Ramírez1, Ignacio López Bueno1, José Manuel Sousa Martín1
1Aparato Digestivo, Hospital Universitario Virgen del Rocío, España.
Abstract:
We report the case of a 58-year-old male patient presenting with clinical and laboratory findings indicative of acute hepatitis. Abdominal ultrasound excluded biliary tract abnormalities. Two weeks prior, the patient had contracted COVID-19. Viral hepatitis was ruled out, and the presence of autoantibodies was confirmed. Liver biopsy findings were consistent with autoimmune hepatitis and grade 1 fibrosis. Initial treatment with budesonide was ineffective, leading to a switch to prednisone, with maintenance therapy comprising prednisone and azathioprine. COVID-19 infection may act as a trigger for the development of autoimmune hepatitis.
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