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DNA response element-based smart drug delivery systems for precise drug release
Jinnan Xuan1,2, Zhen Wang3, Yuting Huang4
1Hubei Key Laboratory of Photoelectric Materials and Devices, School of Materials Science and Engineering, Hubei Normal University, 11 Cihu Road, Huangshi 435002, P. R. China.
Biomaterials Science
|June 4, 2024
Summary
Smart drug delivery systems utilize DNA response elements to control drug release for cancer therapy. These nucleic acid-based systems offer precise and stimulus-responsive therapeutic platforms.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Smart drug delivery systems (DDSs) are crucial for targeted cancer therapy, responding to biological signals or the tumor microenvironment.
- Nucleic acids, due to their self-assembly and programmability, are increasingly used in developing advanced DDSs.
- DNA response elements act as triggers for conformational changes, enabling controlled drug release in DDSs.
Purpose of the Study:
- To review various DNA response elements used in smart DDSs.
- To highlight advancements in DNA response element-based DDSs for precise drug release in biomedicine.
- To discuss future challenges and perspectives in this rapidly evolving field.
Main Methods:
- Review of literature on DNA response elements and their applications in DDSs.
- Categorization of DNA response elements including aptamers, DNAzymes, modified DNA, and photocleavable blocks.
- Analysis of stimulus-responsive properties and their role in controlled drug release.
Main Results:
- Identified diverse DNA response elements (aptamers, DNAzymes, disulfide bond-modified DNA, pH-responsive motifs, photocleavable blocks).
- Demonstrated the potential of these elements in creating sophisticated, stimulus-responsive DDSs.
- Highlighted successful applications of DNA-based DDSs in precise drug delivery for cancer treatment.
Conclusions:
- DNA response elements are versatile tools for developing smart DDSs with tunable drug release capabilities.
- Advancements in DNA-based DDSs show significant promise for targeted cancer therapies.
- Further research is needed to address challenges and fully realize the potential of these advanced therapeutic platforms.
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