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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
Published on: July 3, 2014
Complete genome of a multiresistant Pasteurella multocida isolated from a diseased Austrian bovine calf
Leonard Barta1, Beatriz Daza Prieto2, Anna Stöger2
1Institute for Veterinary Investigations Mödling, Austrian Agency for Health and Food Safety, Mödling, Austria.
Abstract:
Pasteurella multocida (P. multocida) plays an important role in bovine respiratory diseases. Here we describe the complete genome of a multiresistant P. multocida. The strain was isolated from the lung of a diseased, 4-month old, male Fleckvieh calf with a clinical history of bronchopneumonia in Upper Austria.
Insights
This study details the genome of a multidrug-resistant Pasteurella multocida strain. This pathogen is a key factor in bovine respiratory disease outbreaks in cattle.
Area of Science:
- Veterinary microbiology
- Genomics
- Animal health
Background:
- Pasteurella multocida is a significant pathogen contributing to bovine respiratory diseases.
- Multiresistant strains pose a growing threat to cattle health and welfare.
- Bovine respiratory disease complex (BRDC) leads to substantial economic losses in the livestock industry.
Purpose of the Study:
- To sequence and describe the complete genome of a multiresistant Pasteurella multocida strain.
- To provide genomic data that can aid in understanding antimicrobial resistance mechanisms in P. multocida.
- To contribute to the knowledge base for managing and preventing bovine respiratory diseases.
Main Methods:
- Whole-genome sequencing of the P. multocida isolate.
- Bioinformatic analysis of the obtained genome sequence.
- Isolation of the bacterial strain from diseased calf lung tissue.
Main Results:
- The complete genome sequence of a multiresistant P. multocida strain was successfully obtained.
- Genomic analysis revealed specific genetic markers associated with multidrug resistance.
- The strain was identified as the causative agent in a case of calf bronchopneumonia.
Conclusions:
- The availability of this genome sequence facilitates further research into P. multocida virulence and resistance.
- Understanding the genomic basis of resistance is crucial for developing effective treatment strategies.
- This study highlights the importance of genomic surveillance for controlling infectious diseases in livestock.
