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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

541
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

427
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
427

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Biopsy of Iris and Anterior Chamber Tumours: Fine Needle, Minimally Invasive and Excision Techniques - Review.

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Sex-Related Effects on the Clinical Presentation of Uveitis.

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Related Experiment Video

Updated: Jun 24, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Uveitis and Scleritis as a Risk Factor for Mortality.

Joevy Z Lim1,2, Priya D Samalia3,4, Joanne L Sims1

  • 1Department of Ophthalmology, Te Whatu Ora Auckland/Health, Auckland, New Zealand.

Ocular Immunology and Inflammation
|June 4, 2024
PubMed
Summary

Patients with uveitis/scleritis face increased mortality risk, particularly from idiopathic disease and infections like herpes zoster. Mortality risk is highest in the initial years post-diagnosis.

Keywords:
HLA-B27mortalitysarcoidosisscleritisuveitis

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Area of Science:

  • Ophthalmology
  • Immunology
  • Public Health

Background:

  • Uveitis and scleritis are inflammatory eye conditions potentially linked to infections or autoimmune diseases.
  • Understanding the long-term prognosis, specifically all-cause mortality, is crucial for managing these conditions.

Purpose of the Study:

  • To investigate the all-cause mortality rates in patients following their initial diagnosis of uveitis or scleritis.

Main Methods:

  • A 15-year cross-sectional study (2006-2020) of uveitis/scleritis patients at a New Zealand tertiary referral center.
  • Data collected included demographics, etiology, anatomical location, and all-cause mortality.
  • Exclusion criteria: masquerade syndromes like intraocular lymphoma.

Main Results:

  • 2723 patients were analyzed; median age of onset was 44.9 years.
  • Idiopathic disease (30.9%) and HLA-B27-positive uveitis (20.0%) were most common.
  • Higher mortality rates were observed in idiopathic disease, sarcoidosis, Fuchs' uveitis, granulomatosis with polyangiitis, toxoplasmosis, and herpes zoster.
  • Mortality risk peaked within seven years of diagnosis.
  • Patients with uveitis/scleritis had a 1.656 times higher mortality rate than the general population (p=0.017).

Conclusions:

  • Infectious causes of uveitis/scleritis were notably high in this cohort.
  • Shared inflammatory pathways may link ocular and systemic diseases, impacting overall longevity.
  • The findings highlight the significant mortality risk associated with uveitis and scleritis.