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Updated: Jun 24, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
Published on: December 9, 2016
Novel Androgen Receptor Splice Variant 7 in Gynecologic Tumors
Androgen receptor variant 7 (AR-V7) was found in two rare gynecologic cancers. This finding suggests AR-V7 may be a biomarker for targeted therapies in these cancers.
Area of Science:
- Oncology
- Molecular Biology
- Gynecology
Background:
- Androgen receptor splicing variant 7 (AR-V7) is a truncated AR mRNA variant.
- AR-V7 is a potential predictive biomarker for androgen receptor-targeted therapy.
- AR-V7 has been identified in various cancers, including prostate and breast.
Purpose of the Study:
- To investigate the presence and characteristics of AR-V7 in gynecologic cancers.
- To determine the potential role of AR-V7 as a biomarker in gynecologic malignancies.
Main Methods:
- Targeted RNA sequencing was used to detect AR-V7.
- Histopathological examination characterized the tumors.
- DNA methylation profiling was performed.
Main Results:
- AR-V7 was detected in two gynecologic cancers: one in the lower uterine segment and one in the ovary.
- The uterine tumor was an undifferentiated carcinoma, while the ovarian tumor showed cribriform and solid architecture.
- Epigenetic analysis revealed similarities between these AR-V7-positive gynecologic cancers and AR-V7-positive breast cancers.
Conclusions:
- AR-V7 may be present in rare gynecologic carcinomas.
- AR-V7 could serve as a predictive biomarker for targeted therapies in these specific gynecologic cancers.
- The findings suggest a potential link between AR-V7-positive gynecologic and breast cancers.
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