Related Experiment Video
Updated: Aug 14, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
POLE-mutated Endometrial "Carcinosarcoma"
Astrid De Boeck1, Erik Nohr1, Soufiane El-Hallani2
1Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Abstract:
The molecular subtype classification of endometrial carcinomas has conceptually changed our approach to this disease. However, open questions remain about how to integrate certain histotype diagnoses with the molecular subtype. We report 2 cases with morphologic suspicion for endometrial carcinosarcoma, that still fell short of the essential criteria for diagnosing carcinosarcoma. On subsequent molecular testing pathogenic POLE mutations were detected and a descriptive diagnosis of endometrial endometrioid carcinomas, low-grade with a homologous sarcoma component was rendered. This challenges the existence of POLE-mutated "carcinosarcoma."
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