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Parent's perception of respiratory syncytial virus and subsequent wheezing burden: A multi-country cross-sectional

Adnan Custovic1, Jorge Mestre-Ferrandiz2, Leyla Kragten-Tabatabaie3

  • 1National Heart and Lung Institute, Imperial College London, London, UK.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|June 5, 2024
PubMed

Insights

Respiratory Syncytial Virus (RSV) infection significantly increases the risk of subsequent wheezing in children. This wheezing impacts children's quality of life and family well-being.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Respiratory Syncytial Virus (RSV) is a primary cause of infant hospitalizations.
  • RSV bronchiolitis is linked to an elevated risk of developing subsequent wheezing conditions.
  • Understanding parental perceptions of this link is crucial for family support and resource allocation.

Purpose of the Study:

  • To assess parental perception of the association between RSV infection and subsequent wheezing in children.
  • To evaluate the impact of RSV-related wheezing on healthcare utilization and family resources.
  • To document the effect of RSV-associated wheezing on the daily lives of families.

Main Methods:

  • A cross-sectional online survey was conducted with 1200 parents across the US, UK, Spain, and Italy.
  • Participants included parents of children aged ≤6 years.
  • Children were categorized into an RSV group (diagnosed with RSV bronchiolitis before age 2) and a Reference group (never diagnosed with RSV bronchiolitis).

Main Results:

  • Children with a history of RSV bronchiolitis had a 4.5-fold higher odds of wheezing compared to the reference group.
  • Hospitalization or pediatric intensive care admission for RSV bronchiolitis further increased wheezing odds significantly (7.7-fold and 9-fold, respectively).
  • Wheezing substantially impacted children's sleep quality (64%), emotional well-being (57%), daily/social life (53%), and physical activities (46%).

Conclusions:

  • A clear association exists between RSV infection and subsequent wheezing in children internationally.
  • Wheezing, particularly following RSV infection, correlates with increased healthcare use and costs.
  • RSV-associated wheezing significantly disrupts the daily lives and well-being of both children and their families.
Abstract

Keywords:
asthmabronchiolitiscaregiverscross‐sectional surveyinfant healthrespiratory syncytial virus (RSV)wheezing

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