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Updated: Jun 24, 2025
Real-Time Void Spot Assay
Published on: February 10, 2023
Increased prevalence of metabolic syndrome in female patients with overactive bladder: A population-based study
Omer Anis1,2,3, Arnon Dov Cohen4,5, Shachar Aharony6
1Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel.
Objectives:
To assess the association between overactive bladder syndrome (OAB) and the metabolic syndrome (MetS).
Patients And Methods:
A population-based study was conducted to compare OAB patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of the parameters of the MetS, with respect to obesity, hyperlipidemia, hypertension and diabetes mellitus. The characteristics of the OAB population were assessed. Adjusted odds ratios (OR) were calculated by logistic regression.
Results:
110 024 OAB patients and 220 455 controls. were identified. OAB was associated with a higher prevalence of MetS (35.4% vs. 27.5%, p < 0.001). The fully adjusted OR for MetS in patients with OAB compared to controls was 1.44; 95% confidence interval (CI) 1.42-1.46; p < 0.001. Among metabolic parameters, obesity was found to be the strongest factor associated with OAB (OR 1.55, 95% CI 1.53-1.58, p < 0.001), and higher high-density lipoprotein cholesterole levels (>50) had a protective effect on the risk of OAB (OR 0.75, 95% CI 0.73-0.76, p < 0.001).
Conclusions:
Data from this cohort suggest that OAB is positively associated with MetS. Clinicians approaching patients with OAB should be aware of this association. A multimodal treatment focusing on the MetS may be considered in these patients.
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