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The association between smoking exposure and endothelial function evaluated using flow-mediated dilation values: a

Xiaoxiao Jia1, Peng Zhang2, Liping Meng3

  • 1Department of Pathology, Shaoxing People's Hospital, Shaoxing, China.

BMC Cardiovascular Disorders
|June 5, 2024
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Summary

Smoking significantly impairs endothelial function, as measured by flow-mediated dilation (FMD). This meta-analysis confirms smoking

Keywords:
Endothelial functionFlow mediated dilatationSmokemeta-analysis

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Area of Science:

  • Cardiovascular Disease Research
  • Vascular Biology
  • Public Health

Background:

  • Tobacco use is a primary driver of cardiovascular disease.
  • Endothelial dysfunction is a key factor in cardiovascular disease development.
  • Flow-mediated dilation (FMD) is a noninvasive measure of endothelial function.

Purpose of the Study:

  • To investigate the association between smoking exposure and endothelial function using FMD values.
  • To quantify the impact of smoking on endothelial function through a meta-analysis.

Main Methods:

  • Systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library.
  • Inclusion of cohort studies assessing endothelial function in smokers or passive smokers using FMD.
  • Pooled effect size calculated using weighted mean difference; risk of bias assessed.

Main Results:

  • 14 studies comprising 1426 articles were included.
  • Smoking was identified as a significant cause of endothelial dysfunction and altered FMD.
  • A pooled effect size of -3.15 (95% CI: -3.84, -2.46) indicated a negative impact of smoking on FMD.

Conclusions:

  • Smoking exerts a significant detrimental effect on endothelial function.
  • Interventions like smoking cessation medication and education may improve FMD.
  • Improving endothelial function can potentially reduce cardiovascular disease risk.