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Related Experiment Videos

Large-dose fractionation (hypofractionation).

J D Cox

    Cancer
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Large-dose radiation fractionation regimens may decrease tumor control and increase normal tissue effects. Further research into hypofractionation and rapid fractionation is not recommended; focus should be on smaller fractions.

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    Area of Science:

    • Radiation oncology
    • Medical physics

    Background:

    • Fractionation is a key radiotherapy modality influencing tumor control and normal tissue effects.
    • Clinical experience with reduced numbers of large fractions has accumulated over the past 15 years.

    Purpose of the Study:

    • To review literature on tumor control and normal tissue effects associated with hypofractionation, rapid fractionation, and rapid split-course regimens.
    • To evaluate the therapeutic ratio of these large-dose fractionation approaches.

    Main Methods:

    • Literature review of clinical experiences with specific large-dose fractionation regimens.
    • Analysis of data concerning tumor control and late effects on normal tissues.

    Main Results:

    • Hypofractionation, rapid fractionation, and rapid split-course regimens are associated with decreased tumor control.

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  • These large-dose fractionation approaches lead to increased late effects on normal tissues.
  • The overall therapeutic ratio is reduced with these methods.

    • Conclusions:

    • Large-dose fractionation strategies (hypofractionation, rapid fractionation) show a reduced therapeutic ratio and are not recommended for further clinical research or combination with other modalities.
    • Clinical research should instead focus on the effects of increasing the number of smaller fractions in radiotherapy.