Past, present, and future of microbiome-based therapies

Area of Science:

• Microbiology
• Immunology
• Pharmacology

Background:

• Technological advances allow deep study of the human microbiome.
• Microbial signatures are linked to various health and disease states.
• The gut microbiota is crucial for maintaining host homeostasis.

Purpose of the Study:

• To review the gut microbiota's influence on infectious disease and cancer.
• To analyze the bidirectional interaction between gut microbiota and drugs.
• To explore microbiome modulation strategies and their regulatory framework.

Main Methods:

• Literature review of microbiome-based therapies.
• Analysis of host-microbiota interactions.
• Exploration of current and future modulation strategies.

Main Results:

• Gut microbiota influences infectious disease and cancer development.
• Microbiota composition impacts drug efficacy and treatment response.
• Various strategies exist for microbiome modulation, from basic to advanced.

Conclusions:

• Microbiome-based therapies show significant potential for treating diseases like cancer and infections.
• Understanding microbiota-drug interactions is key to optimizing therapeutic outcomes.
• Future therapies may leverage artificial intelligence for personalized microbiome modulation.