Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy
Samantha M McCabe1,2,3, Hannah Gardiner2, Calum Mullen2
1Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK. karen.faulds@strath.ac.uk.
The Analyst
|June 6, 2024
Abstract:
Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.


