Related Experiment Video
Updated: May 5, 2026
12:14
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
35.0K
Circulating interleukins concentrations and post-stroke depression: A systematic review and meta-analysis
Ting Zheng1, Taotao Jiang1, Rundong Li2
1Department of Neurology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China; The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, China.
Summary
Circulating interleukin levels, including IL-1, IL-6, and IL-17, may help diagnose post-stroke depression (PSD). This meta-analysis found distinct interleukin profiles in PSD patients compared to those without depression.
Area of Science:
- Neuroimmunology
- Biomarker Discovery
- Stroke Research
Background:
- Post-stroke depression (PSD) is a common complication affecting patient recovery.
- Identifying reliable biomarkers for PSD is crucial for timely diagnosis and treatment.
- Interleukins, a class of cytokines, are implicated in inflammatory and neurological processes.
Approach:
- A systematic literature search was conducted across eight databases for studies on circulating interleukin concentrations in PSD patients.
- Forty-five studies comparing interleukin levels in PSD patients and stroke patients without depression (NPSD) were included.
- Meta-analysis was performed using RevMan 5.4 software to synthesize the findings.
Key Points:
- PSD patients exhibited higher concentrations of IL-1, IL-4, IL-6, and lower IL-10 compared to NPSD patients.
- Elevated circulating IL-1, IL-6, and IL-18 were observed in the acute phase of PSD.
- Significantly higher IL-6 and IL-17 levels were noted at discharge and at 3-6 months post-stroke in PSD patients.
Conclusions:
- Circulating interleukin concentrations demonstrate potential as diagnostic biomarkers for post-stroke depression.
- Specific interleukin profiles (e.g., elevated IL-6, IL-17) may indicate the presence or risk of PSD.
- Further research can validate these findings for clinical application in stroke patient management.
Related Concept Videos
01:18Depression: Overview
1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
01:15Ischemic Stroke l: Introduction
44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
01:15Ischemic Stroke ll: Pathophysiology
54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54