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Updated: Jun 24, 2025

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
Published on: October 9, 2016
The role of extracellular structures in Clostridioides difficile biofilm formation
Leslie A Ronish1, Baishakhi Biswas2, Robert M Bauer1
1Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Abstract:
C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of many developed countries due to the high rates of nosocomial infections. Despite the availability of several antibiotics with high response rates, effective treatment is hampered by recurrent infections. One potential mechanism for recurrence is the existence of C. difficile biofilms in the gut which persist through the course of antibiotics. In this review, we describe current developments in understanding the molecular mechanisms by which C. difficile biofilms form and are stabilized through extracellular biomolecular interactions.
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