Chronic blisters on aging skin: causes and treatment

Direct immunofluorescence of perilesional tissue in approximately 90% of patients shows a linear or tubular deposition of immunoglobulins--generally IgG and C3--at the basement membrane zone. Mild or localized eruptions can be controlled with topical steroids and wet dressings. If involvement is more extensive, oral prednisone is given in divided doses of 40 to 60 mg/d until the lesions heal.