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The Helsinki Rat Microsurgical Sidewall Aneurysm Model
Published on: October 12, 2014
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Numerical investigation on the impact of different coronary aneurysms morphologies on thrombus formation and
Kaiyue Zhang1, Pan Song2, Yan Pei1
1Department of Computer Science and Technology, Southwest University of Science and Technology, No. 59, Middle of Qinglong Avenue, Fucheng District, Mianyang, 621010, China.
Biomechanics and Modeling in Mechanobiology
|June 6, 2024
Summary
Saccular coronary artery aneurysms (CAAs) show higher risk of rupture due to flow stagnation. Fusiform CAAs, however, pose a greater risk of early obstruction from thrombosis, warranting clinical concern.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Medical Imaging
Background:
- Coronary artery aneurysms (CAAs) are classified as saccular or fusiform.
- Clinical understanding of thrombosis risk in different CAA morphologies remains controversial.
Purpose of the Study:
- To evaluate thrombus growth trends in saccular versus fusiform CAAs.
- To assess long-term complication risks using hemodynamic parameters.
Main Methods:
- Reconstruction of two CAA morphologies from computed tomography angiography (CTA) data.
- Analysis of wall shear stress (WSS) and helicity indicators.
- Application of a thrombus growth model for different CAA morphologies.
Main Results:
- Most WSS indicators showed no significant difference between saccular and fusiform CAAs.
- Saccular CAAs exhibited significantly higher relative residence time (RRT) due to helical flow and stagnation.
- Fusiform CAAs showed potential for earlier main coronary flow channel obstruction by thrombus.
Conclusions:
- Higher RRT in saccular CAAs may increase risks of dilatation or rupture.
- Fusiform CAAs may present a greater clinical concern for early obstruction due to thrombosis.
- Hemodynamic analysis aids in understanding CAA morphology-specific risks.
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