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Acyclovir extravasation in a newborn: a case report

Shirin Shamel1, Mohammad Reza Zarkesh2,3

  • 1Department of Neonatology, Yas Hospital Complex, Tehran University of Medical Sciences, Sarv Ave., North Nejatolahi Street, Tehran, 1598718311, Iran.

Journal of Medical Case Reports
|June 6, 2024
PubMed

Insights

Acyclovir extravasation caused soft tissue damage in a neonate. Prompt management with hyaluronidase, limb elevation, and cold compression led to significant improvement, highlighting the importance of early intervention.

Area of Science:

  • Neonatal care
  • Pediatric pharmacology
  • Dermatology

Background:

  • Acyclovir, an antiviral medication, can cause extravasation injury.
  • Neonates are particularly vulnerable to drug extravasation due to delicate tissues.

Observation:

  • A neonate developed swelling and discoloration after intravenous acyclovir administration.
  • Symptoms appeared shortly after the second dose, indicating a rapid reaction.

Findings:

  • Immediate management included catheter removal, hyaluronidase injection, limb elevation, and cold compression.
  • Significant improvement in swelling and discoloration was observed within 4 hours.

Implications:

  • Early recognition and management of acyclovir extravasation are crucial in neonates.
  • Standardized treatment protocols are needed to optimize outcomes for neonatal extravasation injuries.
Abstract

Keywords:
AcyclovirExtravasationNeonate

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