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Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Phosphorylation01:02

Phosphorylation

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Photoluminescence: Applications01:14

Photoluminescence: Applications

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism01:14

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism

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The Wittig reaction, which converts aldehydes or ketones to alkenes using phosphorus ylides, proceeds through a nucleophilic addition‒elimination process.
The reaction begins with the nucleophilic addition between a phosphorus ylide and the carbonyl compound. Due to its carbanionic character,  phosphorus ylide acts as a strong nucleophile and attacks the electrophilic carbonyl group. This generates a charge-separated dipolar intermediate called betaine. The negatively charged oxygen atom and...
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Phosphodiester Linkages01:01

Phosphodiester Linkages

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Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
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Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
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Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI

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A Phosphanyl Phosphagermene and its Reactivity.

Joey Feld1, Eric S Yang1, Stephanie J Urwin1

  • 1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

A novel phosphagermene, a compound featuring phosphorus and germanium, was synthesized. This compound exhibits unique reactivity, undergoing cycloaddition or addition reactions depending on the coreactant, leading to diverse heterocyclic compounds and metal phosphides.

Keywords:
Double bondsGermaniumPhosphagermenePhosphide ligandsPhosphorus

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Area of Science:

  • Organometallic Chemistry
  • Main Group Chemistry
  • Synthetic Chemistry

Background:

  • Germylenes are reactive species with a divalent germanium atom.
  • Phosphaketene chemistry is less explored, particularly in reactions with germylenes.

Purpose of the Study:

  • To synthesize and characterize a novel phosphanyl phosphagermene.
  • To investigate the reactivity of the P=Ge double bond with various substrates.
  • To explore the potential of this compound as a building block for new heterocycles and metal complexes.

Main Methods:

  • Reaction of a nucleophilic germylene with a phosphanyl phosphaketene.
  • Characterization of the resulting phosphanyl phosphagermene using spectroscopic techniques.
  • Investigation of cycloaddition and addition reactions with CO2, MeCN, amines, and metal complexes.

Main Results:

  • Decarbonylation occurred to form the phosphanyl phosphagermene.
  • The phosphagermene underwent [3+2]-cycloaddition with CO2 and MeCN, yielding five-membered heterocycles.
  • 1,2-addition reactions with ammonia, primary amines, and metal complexes produced metal phosphide complexes.

Conclusions:

  • The synthesized phosphanyl phosphagermene displays dual reactivity, acting similarly to frustrated Lewis pairs or undergoing 1,2-addition.
  • This compound serves as a versatile precursor for synthesizing diverse heterocyclic compounds and metal phosphides in a single step.