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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Updated: Jun 24, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Emerging delivery strategy for oncolytic virotherapy.

Jiao Zhu1,2, Jinhu Ma1, Meijuan Huang2

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Molecular Therapy. Oncology
|June 7, 2024
PubMed
Summary

Oncolytic virotherapy using oncolytic viruses (OVs) shows promise for cancer treatment. Novel nanoparticle and cell-based delivery systems enhance systemic OV administration, improving anti-tumor efficacy and overcoming delivery challenges.

Keywords:
MT: Regular Issueadministration routecell carriercell-derived vesicleclinical trialdelivery strategynanoparticleoncolytic virus

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Area of Science:

  • Oncology
  • Immunotherapy
  • Nanotechnology
  • Virology

Background:

  • Oncolytic virotherapy is a promising cancer immunotherapy.
  • Intratumoral injection of oncolytic viruses (OVs) limits clinical application for metastatic cancers.
  • Systemic administration of OVs faces challenges like immune clearance and poor tumor accumulation.

Purpose of the Study:

  • To review innovative strategies for systemic delivery of oncolytic viruses (OVs).
  • To focus on nanoparticle-based and cell-based delivery systems for OVs.
  • To examine pre-clinical and clinical studies on enhanced OV delivery platforms.

Main Methods:

  • Review of recent pre-clinical and clinical studies.
  • Focus on nanoparticle and cell-based delivery systems for oncolytic viruses.
  • Analysis of strategies to improve systemic OV delivery and anti-tumor efficacy.

Main Results:

  • Nanoparticle and cell-based delivery systems enhance systemic oncolytic virotherapy.
  • Novel platforms improve OV accumulation in tumors and reduce side effects.
  • These strategies show increased anti-tumor efficacy in recent studies.

Conclusions:

  • Systemic delivery of oncolytic viruses (OVs) is crucial for advanced cancers.
  • Nanoparticle and cell-based systems offer effective strategies for OV delivery.
  • Further research and solutions are needed to address current challenges in OV delivery.