Related Experiment Video
Updated: Jun 24, 2025
04:41
Knee Arthrocentesis in Adults
Published on: February 25, 2022
7.4K
Statin use in total joint arthroplasty: a systematic review
Soroush Baghdadi1, Mazyar Babagoli2, Mohammad Soleimani2
1Pediatric Orthopedic Surgery Department, Montefiore Medical Center, New York, USA.
Annals of Medicine and Surgery (2012)
|June 7, 2024
Summary
Statins may reduce complications like atrial fibrillation and delirium in hip and knee replacement patients. Evidence suggests they may also lower long-term revision surgery risk without increasing toxicity.
Area of Science:
- Orthopedic Surgery
- Cardiology
- Pharmacology
Background:
- Growing interest in Statin use for total hip (THA) and knee arthroplasty (TKA) patients.
- Potential benefits include improved outcomes and reduced postoperative complications.
- Systematic review to evaluate Statin efficacy and safety in this population.
Purpose of the Study:
- To systematically review existing evidence on Statin use in THA and TKA.
- To assess the benefits and complications associated with Statin therapy in joint replacement patients.
- To synthesize findings on cardiac, non-cardiac, and long-term outcomes.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Searched PubMed, Embase, Scopus, Web of Science, and Cochrane databases.
- Inclusion criteria focused on studies reporting Statin effects on THA/TKA outcomes.
Main Results:
- 18 papers included; mostly retrospective studies with heterogeneous data.
- Limited and varied evidence on Statin risks and benefits in total joint arthroplasty.
- Studies examined perioperative cardiac, clinical, renal, pulmonary, and GI outcomes.
Conclusions:
- Perioperative Statins may reduce cardiac (e.g., atrial fibrillation) and non-cardiac (e.g., delirium) complications in Statin-naïve patients.
- No increased risk of muscle or liver toxicity observed with Statin use.
- Low-level evidence suggests Statins may decrease long-term risks of revision surgery and osteolysis.
Related Concept Videos
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
647
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
647
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
519
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
519
01:20The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K