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The immunohistochemical expression of c-MET and RON in lung adenocarcinoma with clinicopathologic correlation
Young-Ah Kim1,2, Woo Jung Sung1
1Department of Pathology, Daegu Catholic University School of Medicine, Duryugongwon-ro 17-gil 33, Nam-gu, Daegu 42472, Republic of Korea.
Background:
Mesenchymal epidermal transition (MET) and receptor originating from nantes (RON) are transmembrane tyrosine kinase receptors. Both are members of a proto-oncogene family and thus play a role in the pathogenesis of various cancers and acquired resistance to kinase inhibitors in lung cancer.
Aims:
The aim of this study was to investigate the immunohistochemical expression of c-MET and RON in lung adenocarcinoma and its clinicopathologic correlation.
Settings And Design:
Retrospective study.
Materials And Methods:
The immunohistochemical c-MET and RON expression in specimens obtained from lung adenocarcinoma ( n = 175) and associated clinicopathologic parameters were evaluated.
Statistical Analysis Used:
The correlation between c-MET and RON expression was analyzed by Chi-square test. A Cox proportional hazards model and Kaplan-Meier curve analysis were used to evaluate the risk factors and prognosis.
Results:
High expression of the c-MET protein showed a strong correlation with that of RON ( P = 0.013, kappa = 0.183). Five-year survival and recurrence-free 5-year survival were not associated with high expression of c-MET or RON. High c-MET expression was significantly associated with age older than 60 years ( P = 0.000), tumor differentiation ( P = 0.009), lymphovascular invasion ( P = 0.016), and pleural invasion ( P = 0.005). High RON expression was associated with a solid growth pattern ( P = 0.001) and pleural invasion ( P = 0.002).
Conclusions:
The results point to the potential of immunohistochemical expression of c-MET and RON as useful prognostic markers of unfavorable histopathologic features in lung adenocarcinoma.
Insights
High expression of c-MET and RON proteins correlates with unfavorable histopathologic features in lung adenocarcinoma, but not survival outcomes. These markers may aid in identifying aggressive tumor characteristics.
Area of Science:
- Oncology
- Molecular Biology
Background:
- Mesenchymal-epithelial transition (MET) and receptor originating from Nantes (RON) are transmembrane tyrosine kinase receptors involved in cancer pathogenesis.
- Both MET and RON are proto-oncogenes implicated in acquired resistance to kinase inhibitors in lung cancer.
Purpose of the Study:
- To investigate the immunohistochemical expression of c-MET and RON in lung adenocarcinoma.
- To correlate c-MET and RON expression with clinicopathologic parameters.
Main Methods:
- Retrospective study of 175 lung adenocarcinoma specimens.
- Immunohistochemistry was used to evaluate c-MET and RON expression.
- Statistical analyses included Chi-square test, Cox proportional hazards model, and Kaplan-Meier analysis.
Main Results:
- High c-MET and RON expression showed a significant correlation (P = 0.013).
- Neither high c-MET nor RON expression was associated with 5-year survival or recurrence-free survival.
- High c-MET expression correlated with older age, poor tumor differentiation, lymphovascular invasion, and pleural invasion.
- High RON expression was associated with solid growth pattern and pleural invasion.
Conclusions:
- Immunohistochemical expression of c-MET and RON may serve as prognostic markers.
- These markers are associated with unfavorable histopathologic features in lung adenocarcinoma.
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