Molecular Breast Imaging Biopsy with a Dual-Detector System

Area of Science:

• Radiology
• Oncology
• Medical Device Development

Background:

• Molecular Breast Imaging (MBI) offers functional information for breast lesion detection.
• Accurate targeting of lesions for biopsy is crucial for diagnosis and treatment planning.
• Existing biopsy systems may have limitations in targeting MBI-identified lesions.

Purpose of the Study:

• To develop and evaluate a novel dual-detector Molecular Breast Imaging (MBI)-guided biopsy system.
• To assess the feasibility, safety, and efficiency of this MBI-guided biopsy system in participants.

Main Methods:

• A prospective study utilized a dual-detector MBI system with a retractable upper detector for biopsy.
• Lesion depth was calculated using triangulation and activity on both detectors.
• Participants with suspicious breast lesions underwent MBI-guided biopsy after technetium 99m sestamibi injection.

Main Results:

• The MBI-guided biopsy system was successfully implemented in 21 participants.
• Seventeen participants had MBI-guided biopsies with concordant pathology, demonstrating diagnostic accuracy.
• The average procedure time was 55 minutes, indicating efficiency.

Conclusions:

• Dual-detector Molecular Breast Imaging (MBI)-guided biopsy with a retractable upper detector is feasible.
• The system is well-tolerated and efficient for sampling breast lesions.
• This technology represents a promising advancement in image-guided breast biopsy.