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Glutamine-derived peptides: Current progress and future directions.

Tianfei Yu1, Tianshuo Hu1, Kai Na1

  • 1College of Life Science, South-Central Minzu University, Wuhan City, China.

Comprehensive Reviews in Food Science and Food Safety
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

Glutamine-derived peptides offer enhanced functionality over glutamine monomers for nutrition. AI and synthetic biology can unlock their potential in food science and health applications.

Keywords:
artificial intelligencebioactivityde novo design and mass productionglutaminepeptide

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Area of Science:

  • Nutritional Science
  • Biotechnology
  • Food Science

Background:

  • Glutamine is vital for immune function, intestinal integrity, and nitrogen balance.
  • Limited solubility and instability of glutamine monomers hinder their use as functional nutrients.
  • Glutamine-derived peptides are preferred for enhanced functionality and bioavailability.

Purpose of the Study:

  • To review glutamine monomer applications in clinical, sports, and enteral nutrition.
  • To compare the functional effectiveness of glutamine monomers and peptides.
  • To assess glutamine-derived peptides' classification, preparation, absorption, and bioactivity, exploring AI and synthetic biology integration.

Main Methods:

  • Literature review of glutamine and glutamine-derived peptide applications.
  • Comparative analysis of monomer vs. peptide functionality.
  • Exploration of AI-based peptidomics and synthetic biology for peptide design and production.

Main Results:

  • Glutamine-derived peptides exhibit significant structure-related bioactivities, with smaller molecular weight fractions being key.
  • These peptides promote intestinal homeostasis, exhibit hypotensive and hypoglycemic effects, and possess antioxidant properties.
  • Structure-function relationships of glutamine-derived peptides require further exploration.

Conclusions:

  • Glutamine-derived peptides offer superior functional benefits compared to monomers.
  • AI and synthetic biology can drive innovation in glutamine-derived peptide discovery and production.
  • Further research into structure-function relationships and delivery systems is crucial for optimizing their use as functional food ingredients.