Mannuronate Oligosaccharides Ameliorate Experimental Colitis and Secondary Neurological Dysfunction by Manipulating...

Area of Science:

• Gut microbiota
• Neuroscience
• Alginate oligosaccharides

Background:

• Microbiota dysfunction is linked to intestinal and neurological disorders.
• Mannuronate oligosaccharides (MAOS), a type of alginate oligosaccharide (AOS), show potential in modulating gut microbiota and cognitive function.
• The precise mechanisms and regulatory factors of MAOS in the gut-brain axis are not fully understood.

Purpose of the Study:

• To investigate the effects of MAOS on the gut-brain axis in vivo and in vitro.
• To identify key regulatory factors and mechanisms involved in MAOS-mediated protection.
• To explore the potential of MAOS in preventing colitis and neurological disorders.

Main Methods:

• In vivo and in vitro experiments were conducted.
• Dextran sodium sulfate (DSS)-induced colitis model was used.
• The TLR4/MyD88/NF-κB signaling pathway was analyzed.

Main Results:

• MAOS pretreatment significantly alleviated DSS-induced colitis and secondary nerve injury.
• MAOS regulated serum 1,2-dipalmitoylphosphatidylcholine (DOPC) abundance.
• MAOS inhibited the TLR4/MyD88/NF-κB pathway, impacting the gut-brain axis.

Conclusions:

• Dietary MAOS play a crucial role in preventing colitis and neurological disorders.
• MAOS exert protective effects by modulating the gut-brain axis via the TLR4/MyD88/NF-κB pathway.
• MAOS demonstrate potential as functional food ingredients for disease prevention.