A case-control study: epigenetic age acceleration in psoriasis.
Betul Macit1, Sara D Ragi2, Isabelle Moseley2
1Department of Dermatology, Warren Alpert Medical School, Brown University, 339 Eddy Street, Providence, RI, 02903, USA.
Psoriasis (PsO) and psoriatic arthritis (PsA) may accelerate biological aging. PsA cases showed accelerated PhenoAge, suggesting a link between inflammation and epigenetic aging in this condition.
Area of Science:
- Epigenetics and aging research
- Dermatology and immunology
Background:
- Psoriasis (PsO) is a chronic inflammatory skin disease often co-occurring with psoriatic arthritis (PsA).
- This study investigated the association between PsO and accelerated biological aging using epigenetic DNA methylation clocks.
Discussion:
- No significant differences in epigenetic ages were found between PsO cases and controls.
- PsO cases with co-occurring PsA exhibited accelerated PhenoAge compared to matched controls, indicating a potential impact of PsA on biological aging.
Key Insights:
- Psoriatic arthritis (PsA) may be linked to accelerated epigenetic aging, specifically measured by PhenoAge.
- Heightened inflammatory burden in PsA could contribute to this accelerated aging process.
Outlook:
- Further research is needed to explore the systemic effects of PsA on aging.
- Larger, diverse studies are essential to identify PsO subgroups with accelerated aging and understand the interplay between PsO, inflammation, and aging.
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