Related Experiment Video

Updated: Jun 24, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

323

Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy

Wencan Zhang1, Xu Cao2, Hongmin Wu1

  • 1Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.

Critical Reviews in Immunology
|June 7, 2024
PubMed

Insights

Steroid receptor coactivators (SRCs) regulate T cell function and cancer cell metabolism. This review explores SRC roles in both, discussing targeting SRCs for cancer immunotherapy.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Steroid receptor coactivators (SRCs) are key transcriptional co-regulators involved in gene expression.
  • Overexpression of SRCs is linked to various cancers, particularly hormone-related types.
  • SRCs influence tumor progression, metastasis, and chemoresistance through metabolic pathway regulation.

Purpose of the Study:

  • To review the function of SRCs in T cells and cancer cells.
  • To discuss the controversies and potential strategies for targeting SRCs in cancer immunotherapy.

Main Methods:

  • Literature review of studies on SRC function in T cells and cancer.
  • Analysis of emerging evidence on SRC-mediated metabolic regulation.
  • Discussion of current controversies in SRC-targeted cancer immunotherapy.

Main Results:

  • SRCs regulate T cell maturation, differentiation, and cytotoxicity via metabolic control.
  • SRCs are implicated in tumor growth, invasion, metastasis, and chemoresistance.
  • Evidence suggests SRCs play dual roles in cancer immunity.

Conclusions:

  • SRCs are critical regulators in both T cells and cancer cells.
  • Targeting SRCs presents complex challenges and opportunities for cancer immunotherapy.
  • Further research is needed to reconcile controversies and develop effective SRC-targeting strategies.

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