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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Engineering focusing on cancer.

Kayvan R Keshari1, Daniel A Heller2, Rostislav Boltyanskiy3

  • 1Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Gerstner Sloan Kettering School for Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Center for Molecular Imaging and Bioengineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cancer Cell
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

Cancer engineering merges engineering and biology to improve cancer research, diagnosis, and treatment. This emerging field requires dedicated centers and education to train scientists for transforming cancer care.

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Area of Science:

  • Biomedical Engineering
  • Cancer Biology
  • Translational Science

Background:

  • Cancer research has advanced significantly but lacks engineering integration.
  • Engineering approaches offer novel methods for understanding, diagnosing, and treating cancer.
  • A gap exists in synergistic collaboration between engineering and cancer biology.

Purpose of the Study:

  • To introduce and define cancer engineering as an emerging subfield.
  • To highlight the challenges and opportunities within cancer engineering.
  • To advocate for dedicated infrastructure and educational programs.

Main Methods:

  • Review and synthesis of current trends in cancer research and biomedical engineering.
  • Identification of key challenges in interdisciplinary collaboration.
  • Proposal of strategies for educational and institutional development.

Main Results:

  • Cancer engineering integrates engineering principles with cancer biology.
  • Dedicated centers and departments are crucial for translational research.
  • Educational initiatives are needed to foster expertise in cancer engineering.

Conclusions:

  • Cancer engineering holds significant potential to revolutionize cancer care.
  • Interdisciplinary collaboration and specialized education are essential for its advancement.
  • Strategic development of infrastructure and training programs will accelerate progress in the field.