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Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
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Association between Life's Essential 8 and cataract among US adults
Yang Meng1, Zongbiao Tan2, Abdulla Sawut1
1Department of Ophthalmology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, China.
Scientific Reports
|June 7, 2024
Summary
Improving cardiovascular health through Life's Essential 8 (LE8) indicators, particularly physical activity, sleep, and blood glucose, is linked to a reduced risk of developing cataracts. Higher LE8 scores indicate better cardiovascular health and lower cataract incidence.
Area of Science:
- Cardiovascular Health
- Ophthalmology
- Public Health
Background:
- A comprehensive assessment of the relationship between ideal cardiovascular health (CVH) indicators and cataract risk is lacking.
- Life's Essential 8 (LE8) is the latest concept by the American Heart Association to reflect CVH status, encompassing health behaviors and factors.
- Cataract is a leading cause of vision impairment, and understanding modifiable risk factors is crucial for prevention.
Purpose of the Study:
- To evaluate the association between the Life's Essential 8 (LE8) score and cataract risk.
- To investigate the correlation between individual LE8 components and cataract.
- To explore potential nonlinear relationships between CVH status and cataract.
Main Methods:
- Cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data (2005-2008).
- Inclusion of 2720 non-cataract and 602 cataract participants.
- Weighted multiple logistic regression and restricted cubic spline analysis were employed, adjusting for confounding variables.
Main Results:
- A higher LE8 score was inversely associated with cataract risk; each 10-point increase reduced risk by 14% (OR=0.86, 95% CI: 0.79-0.93).
- The proportion of cataract participants was significantly lower in the ideal CVH group (14.1%) compared to intermediate (18.2%) and poor (20.6%) groups (P<0.05).
- Physical activity, sleep, and blood glucose were significantly associated with cataract risk (P<0.05).
Conclusions:
- Better cardiovascular health, as indicated by a higher LE8 score, is associated with a lower risk of cataract.
- Improving LE8 components, specifically physical activity, sleep, and blood glucose management, may offer a novel strategy for cataract risk reduction.
- These findings highlight the importance of holistic cardiovascular health in preventing eye diseases like cataracts.
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