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[Biopolymers and evolution].

M V Vol'kenshteĭn

    Molekuliarnaia Biologiia
    |January 1, 1985
    PubMed
    Summary

    Biopolymer evolution requires studying proteins and nucleic acids within metabolic networks, not just isolated structures. Molecular evolution and biological evolution are distinct processes, with neutral theory explaining molecular changes.

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    [Conformational analysis of anti-arrhythmia agents of the lidocaine series and a model for the mechanism of their action].

    Biofizika·1988

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Evolutionary Biology

    Context:

    • Traditional biopolymer studies often overlook crucial cellular context.
    • Understanding proteins and nucleic acids within metabolic networks is essential for evolutionary analysis.

    Purpose:

    • To investigate the behavior and evolution of proteins and nucleic acids in metabolic networks.
    • To explore the relationship between primary structure, spatial structure, and function in biopolymers.
    • To present evidence supporting the neutral theory of evolution at the molecular level.

    Summary:

    • Biopolymers, like proteins and nucleic acids, exhibit properties influenced by their cellular environment and metabolic network integration.
    • Amino acid substitutions are viable if they preserve protein structure and function, with degeneracy in structure-function correlations.
    • Deleterious mutations can be compensated by regulatory changes in synthesis (amount, space, time), highlighting the importance of 'how much, when, and where'.
    • The theory of evolution integrates phylogeny and ontogeny, suggesting that evolutionary directionality is shaped by both natural selection and intrinsic organismal structure, leading to non-adaptive traits at the molecular level.

    Impact:

    • Provides a molecular basis for neutral evolution, reconciling molecular and biological evolution.
    • Highlights the significance of post-translational modifications and gene regulation in molecular evolution.
    • Challenges purely adaptive explanations for molecular evolution, emphasizing the role of constraints and historical contingency.

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