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Reduction in amniocentesis risks using a real-time needle guide procedure.

R A Williamson, M W Varner, S S Grant

    Obstetrics and Gynecology
    |May 1, 1985
    PubMed
    Summary
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    Second trimester genetic amniocentesis is a safe procedure with a low complication rate. Fetal deaths occurred in less than 1% of cases, with no immediate post-procedure deaths observed.

    Area of Science:

    • Obstetrics and Gynecology
    • Medical Genetics
    • Fetal Medicine

    Background:

    • Genetic amniocentesis is a common prenatal diagnostic procedure.
    • Assessing complication rates is crucial for patient counseling and procedural safety.

    Purpose of the Study:

    • To evaluate the complication rates of second trimester genetic amniocentesis.
    • To determine the incidence of fetal death and other complications following the procedure.

    Main Methods:

    • A prospective study of 918 patients undergoing second trimester genetic amniocentesis.
    • Continuous sector scanning guidance and an attached needle guide were utilized.
    • Complete infant follow-up was obtained for all cases.

    Main Results:

    Related Experiment Videos

    • Eight fetal deaths occurred in 903 singleton pregnancies (0.89%) at less than 28 weeks post-procedure.
    • No fetal deaths were observed within two weeks of amniocentesis.
    • Only one amniotic fluid sample was visibly blood contaminated.

    Conclusions:

    • Second trimester genetic amniocentesis, when performed with ultrasound guidance, demonstrates a low rate of serious complications.
    • The procedure appears safe with minimal risk of fetal loss directly attributable to the procedure itself.