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Adjunctive hyperbaric oxygen treatment for challenging pyoderma gangrenosum cases
Emma L Hodson1, Allison Kranyak2, Iman Salem1
1Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Journal of Tissue Viability
|June 9, 2024
Summary
Pyoderma gangrenosum (PG) is a rare skin condition. Hyperbaric oxygen therapy (HBOT) may be an effective adjunctive treatment for refractory PG cases, aiding remission.
Area of Science:
- Dermatology
- Wound Healing
- Hyperbaric Medicine
Background:
- Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic skin disease with limited treatment options.
- Disease remission in PG is often challenging to achieve.
- Hyperbaric oxygen therapy (HBOT) is underutilized for PG despite its potential in ulcerative conditions.
Observation:
- A case of treatment-resistant PG is presented.
- The patient achieved remission with the addition of HBOT.
- The patient experienced difficulty achieving remission during a subsequent flare without HBOT.
Findings:
- Adjunctive hyperbaric oxygen therapy (HBOT) can induce remission in refractory pyoderma gangrenosum (PG).
- Discontinuation of HBOT may be associated with challenges in managing future PG flares.
Implications:
- HBOT warrants greater consideration as a therapeutic option for pyoderma gangrenosum.
- Further research into HBOT's role in PG management is recommended.
- This case highlights the potential benefits of HBOT for severe, treatment-resistant cutaneous ulcerative conditions.
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