Related Experiment Video

Updated: Jun 24, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Safely Doing Less Antibiotics: Evidence to Guide Duration and Route of Administration in Common Pediatric Infections

Alaina Shine, Polina Frolova Gregory, Shayna Herns

    Pediatric Annals
    |June 9, 2024
    PubMed

    Insights

    Recent evidence supports shorter antibiotic courses and switching to oral medication early for common pediatric infections. This review provides guidance on antibiotic duration and route for specific childhood illnesses.

    Area of Science:

    • Pediatric infectious diseases
    • Antimicrobial stewardship
    • Pharmacology

    Background:

    • Growing evidence highlights adverse effects of antibiotic exposure in children.
    • Urgent need to reassess current pediatric antibiotic guidelines.
    • Concerns regarding prolonged antibiotic courses and intravenous administration.

    Purpose of the Study:

    • To provide evidence-based guidance on antibiotic course duration and route of administration for common pediatric infections.
    • To support clinicians in optimizing antimicrobial therapy for children.
    • To address specific infections like community-acquired pneumonia, osteomyelitis, and head and neck infections.

    Main Methods:

    • Comprehensive literature review of recent studies on pediatric antibiotic therapy.
    • Analysis of evidence supporting shortened antibiotic durations.
    • Evaluation of data on intravenous to oral antibiotic conversion strategies.

    Main Results:

    • Strong evidence supports shorter antibiotic durations for uncomplicated pediatric infections.
    • Early conversion from intravenous to oral antibiotics is often appropriate.
    • Guidance is provided for specific conditions including pneumonia, osteomyelitis, and head/neck infections.

    Conclusions:

    • Optimizing antibiotic duration and route can improve patient outcomes and reduce adverse effects.
    • Clinicians should consider shortened courses and early oral switch for eligible pediatric patients.
    • This review offers practical recommendations for common pediatric infectious diseases.

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